Turkey Tetrazzini with Mushrooms

Turkey Tetrazzini is a baked turkey and pasta casserole, great for dinner over weekend after thanksgiving. With only 10 minutes prep, this casserole comes together fast and makes homey pasta dinner.

Turkey Tetrazzini with Mushrooms

Today, I'm giving you a delicious family-style turkey casserole recipe, made with Thanksgiving leftovers!

Turkey Tetrazzini is a baked turkey and pasta casserole which is great for dinner over weekend after thanksgiving. With only 10 minutes prep, this casserole comes together very fast and makes homey and flavorful meal. 

In my home, be it Diwali, thanksgiving or a special occasion.. I always have some extra supplies so that I never run short of food.  This also saves us from some last minute trips to grocery stores. (life saver!) 

After holiday's food and festivities comes the leftovers! Even when we are visiting friends, we end up coming home with leftovers - turkey, stuffing, pies and a lot more. So, every year this time, I'm making leftovers "stars" of my everyday meals such as this Turkey Casserole.

Turkey and Chipotle Potato Tacos, Turkey Stuffing and Crab Apple Salad, and Turkey Pot Pie are few of my other old favorites. 

Turkey Tetrazzini Casserole with leftover turkey mushrooms and pasta | chefdehome.com

Even though this Turkey Tetrazzini casserole recipe uses leftover turkey.. I added a lots of flavor in it to make it not-boring and not mere repetition of Thanksgiving-on-the-plate. Here is what I did to lighten-up and develop flavors in this comforting dish:

1) I added a serving of fresh mushrooms and green beans with fresh herbs - thyme and parsley.
2) Instead of making a traditional creamy base of flour, butter and heavy cream... I used a can of Campbell's® Cream of Mushroom Soup with milk. Soup also enhanced the overall mushroom flavor in casserole. 
3) To cut the richness, I added some sun-dried tomatoes and lemon zest. 
4) Last but not least.. seasoned bread crumbs topping (made with olive oil instead of butter) gave  tetrazzini a scrumptious yet lite and crunchy crust.

Sauteing the mushroom and aromatics, and herbs with sun-dried tomatoes makes a flavor base for turkey tetrazzini. After aromatics and veggies are soft, I add a can of cream of mushroom soup, milk and Swanson® Chicken broth in same pot and cook until it gets thick and creamy like béchamel sauce. 

Turkey Tetrazzini Ingredients | chefdehome.com

Turkey Tetrazzini Ingredients | chefdehome.com

I highly recommend using the Mushroom Soup and Chicken broth for this recipe. Cream of Mushroom Soup is the flavor base for turkey casserole... also giving it traditional-like creamy mushroom sauce base. Chicken broth adds an another layer of flavor giving new life to Thanksgiving leftovers.

Easy Turkey and Pasta Casserole | chefdehome.com

Oh, and if you making Turkey stuffing?! I'm sure you are!! Then go buy some Swanson® Chicken broth and save some to make Turkey Tetrazzini next weekend! You can also get discount on both products by visiting the links above.

Now, don't worry if don't have turkey leftovers or if you want to enjoy this recipe before Thanksgiving.. ;-)  Simply use cooked shredded chicken or any protein of your choice. If you follow the rest of the recipe, any protein will taste great in Tetrazzini. Easy! right? 

I'm so excited for the coming holidays, long weekend and fun times to spend with friends and family. I hope and wish these holidays bring lots of joy to you. Eat responsibly and save leftovers to make a lots of meals in remembrance of holidays.. 

Turkey and Pasta Casserole with Mushrooms | chefdehome.com

PS: Remember? I told you, I'm making Sweet Potato Casserole for a Thanksgiving Potluck! It went great and everyone loved my casserole. No leftovers :)  

Enjoy! -Savita

Here are few more ways to utilize Thanksgiving Leftovers:

Leftover Sweet Potato Hand Pies Leftover Roasted Turkey and Mushrooms Pot Pie Kimchi Mashed Potatoes Cakes

Turkey Tetrazzini with Mushrooms

5 (1 review)
Turkey Tetrazzini with Mushrooms
Total Time: Prep Time: Cook Time: Cuisine: American () Difficulty: Easy
Yields: 4-5 Servings - Serves: 4
(No. of servings depends on serving size.)


Turkey Tetrazzini
Mushroom Cream Sauce
Smart Swap: Replace turkey with chicken or veggies.


  • 1. Preheat oven at 425 degrees Fahrenheit. Cook spaghetti according to package directions. Cook until it still has bite since it will be cooked again when tetrazzini is baked.
  • Step for Recipe - Turkey Tetrazzini with Mushrooms 2. While pasta is cooking, heat 1 tbsp oil in a deep saute pan. Add mushrooms and cook until water evaporates (2-3 minutes). Add diced onion, garlic, sun-dried tomatoes and thyme with pinch of black pepper and salt. Cook until onions are soft. (2-3 minutes)
  • Step for Recipe - Turkey Tetrazzini with Mushrooms 3. Add cream of mushroom soup, 1 cup chicken stock and 1/2 cup milk.
    Step for Recipe - Turkey Tetrazzini with Mushrooms 4. Bring to boil. Let it cook for 3-4 minutes or until sauce thickens. Taste and adjust salt.
  • Step for Recipe - Turkey Tetrazzini with Mushrooms 5. Add in shredded leftover turkey, drained green beans, cooked and drained spaghetti noodles. Add in lemon zest, chopped parsley. Toss gently to combine.
    Step for Recipe - Turkey Tetrazzini with Mushrooms 6. To bake Turkey Tetrazzini, spray a 2 quart baking dish/casserole with cooking oil or coat with butter. Pour all ingredients. Mix breadcrumbs with remaining olive oil, and spread over evenly. Bake for 18-20 minutes or until it is bubbly and breadcrumbs are brown and crispy.
  • Step for Recipe - Turkey Tetrazzini with Mushrooms 7. Let it rest for 5-10 minutes before serving. Serve and enjoy!

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16 Responses

  1. My brother and I get together each week for Monday Night Football at my house. I recently hosted the extended family for Thanksgiving dinner, and have loads of leftover turkey. I’m going to make this for our next game dinner. Thanks for the Just-in-Time recipe!
  2. Made this today. I didn't have lemon on hand so i used white wine. This is delicious!
    hi there!, thanks! I'm glad you enjoyed this casserole. White wine instead of lemon is sure a smart move! thanks for taking time to write feedback.
  3. This has delicious written all over it. Great use of Thanksgiving leftovers.
    thanks Platter Talk. Can't have enough of thanksgiving leftovers.
  4. This is perfect fall comfort food! I can't wait to try it with leftover turkey.
    Thanks Allison! I hope you get chance to try these soon! Put leftovers to best use :)
  5. I personally love leftovers and casseroles. This is a great idea. I also usually come home from Thanksgiving with lots of leftovers.
    Ditto! Stephanie, thanks! Our love for casseroles is certainly mutual.
  6. This sounds like a real down-home kind of dinner - I'll bet the whole family loves it! And such a good idea for your leftover turkey!
    Indeed it is, Lisa! I love using leftovers several way during this season and this one is sure family favorite in my home. thanks for stopping by and sharing your thoughts.
  7. I hate wasting any food so this is right up my street. It's a great way to use up leftovers and really good comfort food at the same time.
    Angela, thanks for sweet words. We can always go creative with leftovers.
  8. This recipe sounds so good. I will try it with chicken. Thanks for sharing, Savita!
    thanks Neeli! Leftover chicken will go equally well with this casserole.
  9. I love Thanksgiving leftovers...almost more than the actual Thanksgiving meal itself! What a fun way to use leftover turkey. I'm definitely going to try and save some leftover turkey this year to make this tetrazzini...it sounds delicous! Thanks for sharing! #client